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| Product Code | Proficiency Test | Matrix | Approx. Size |
|---|---|---|---|
|
FCVD29-MRP37
|
02669 |
Rabbit Muscle |
40 g |
sulfonamides & trimethoprim & macrolides
View full analyte list for this specification
1 or more analytes will be present for identification and quantification.
Trimethoprim is a diaminopyrimidine antimicrobial agent which is effective against a wide range of Gram-positive and Gram-negative organisms. In veterinary medicine, trimethoprim is commonly used in combination with sulphonamides. This is because they work synergistically, inhibiting two separate, sequential steps in bacteria. This combination is more effective than either drug alone because it blocks the pathway at two points, making the antibiotics bactericidal (killing bacteria) rather than just bacteriostatic (preventing bacteria from reproducing).
As with other antimicrobial agents there is concern that consumption of food containing trimethoprim may lead to strains of resistant bacteria being formed, therefore Trimethoprim is monitored has its own maximum residue limit.
Sulfonamides make up a significant proportion of veterinary medicines, and as such effectiveness of detection and quantification is key to promote safe foodstuffs for consumption. With a non-targeted detection method needed, key challenges of laboratory testing abilities can be made using proficiency testing to effectively evaluate your capabilities in a simulated environment.
Macrolides are broad spectrum antibiotics often used to treat gram-positive bacterial infections in a wide variety of food-producing animals. They are used to treat both systemic and local infections and are often regarded as alternatives to penicillins for treatment of streptococcal and staphylococcal infections. They have the advantage of producing less inflammatory effects than other drugs. Veterinary drug residues are monitored to control the emergence of antimicrobial resistance (AMR) in bacteria, prevent environmental contamination and assess effectiveness or potential for adverse effects in animals. To regulate their use in the EU, the Commission has set maximum residue limits (MRLs) in animal-derived food products. Monitoring for compliance with such limits has produced the need for analytical methods to measure these drugs at trace residue levels.
Animal products for human consumption are tightly legislated and closely monitored for compliance. Veterinary medicines used in animals are likely to have a pharmacological effect in humans. Hence, for many veterinary medicines, there are extremely low maximum residue limits or even no MRL (i.e. any detection is non-compliant). The Fapas test materials are produced in keeping with EU MRLs or minimum required performance limit (MRPL) where MRLs are not set. The result reporting requirements are also in keeping with quality control guidelines laid out in EC/657/2002. Fapas veterinary medicine test materials include incurred residues, as well as fortified animal products, and are suitable for all methods, including screening methods (for the detection of the total amount of that chemical class).
Fapas veterinary medicine PT materials include incurred residues as well as fortified animal products and by combining identification and quantification, your lab can be challenged to simulate real routine testing. The PTs are suitable for all methods, including screening methods (for the detection of the total amount of that chemical class).
